15
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The effect of sphingosine-1-phosphate on bone metabolism in humans depends on its plasma/bone marrow gradient.

      Journal of Endocrinological Investigation
      Springer Science and Business Media LLC
      Gradient, Bone marrow S1P, Hip fracture, Osteoporosis, Plasma S1P

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Although recent studies provide clinical evidence that sphingosine-1-phosphate (S1P) may primarily affect bone resorption in humans, rather than bone formation or the osteoclast-osteoblast coupling phenomenon, those studies could not determine which bone resorption mechanism is more important, i.e., chemorepulsion of osteoclast precursors via the blood to bone marrow S1P gradient or receptor activator of NF-κB ligand (RANKL) elevation in osteoblasts via local S1P.

          Related collections

          Author and article information

          Journal
          26219613
          10.1007/s40618-015-0364-x

          Gradient,Bone marrow S1P,Hip fracture,Osteoporosis,Plasma S1P

          Comments

          Comment on this article

          scite_