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      The retinal pigment epithelium in health and disease.

      1 , ,
      Current molecular medicine
      Bentham Science Publishers Ltd.

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          Abstract

          Retinal pigment epithelial cells (RPE) constitute a simple layer of cuboidal cells that are strategically situated behind the photoreceptor (PR) cells. The inconspicuousness of this monolayer contrasts sharply with its importance [1]. The relationship between the RPE and PR cells is crucial to sight; this is evident from basic and clinical studies demonstrating that primary dysfunctioning of the RPE can result in visual cell death and blindness. RPE cells carry out many functions including the conversion and storage of retinoid, the phagocytosis of shed PR outer segment membrane, the absorption of scattered light, ion and fluid transport and RPE-PR apposition. The magnitude of the demands imposed on this single layer of cells in order to execute these tasks, will become apparent to the reader of this review as will the number of clinical disorders that take origin from these cells.

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          Author and article information

          Journal
          Curr Mol Med
          Current molecular medicine
          Bentham Science Publishers Ltd.
          1875-5666
          1566-5240
          Dec 2010
          : 10
          : 9
          Affiliations
          [1 ] Department of Ophthalmology, Columbia University, New York, NY 10032, USA. jrs88@columbia.edu
          Article
          CMM # 78 NIHMS602591
          10.2174/156652410793937813
          4120883
          21091424
          4bf71ab3-54ee-40ec-9e06-8da8ad71c584

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