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Biological variation for N-Terminal Pro- and B-type natriuretic peptides and implications for therapeutic monitoring of patients with congestive heart failure
Alan H.B. Wu ,
Andrew Smith ,
Stacey Wieczorek ,
Jeffrey F. Mather ,
Bret Duncan ,
C.Michael White ,
Carol McGill ,
Deb Katten ,
Gary Heller
September 2003
September 2003
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Abstract
Given the limitations of low enrollments, this study suggests that a change of 130%
for B-type natiuretic peptide (BNP) and 90% for N-terminal (NT)-proBNP are necessary
before results of serially collected data can be considered statistically different.
This study also shows that there are important differences in the performance of BNP
versus NT-proBNP in monitoring patients with congestive heart failure that need to
be further explored.