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      Pressor Responses of Rat Isolated Tail Arteries to Contractile Stimulation after Methylene Blue Treatment: Effect of Adventitial versus Intimal Entry

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          Abstract

          To test the hypothesis that drug entry site (intimal vs. adventitial surface) may be an important determinant of methylene blue (MB) action on vascular reactivity to contractile stimulation, we used preparations of rat isolated tail arteries perfused at constant flow (2 ml/min). Perfusion pressure changes reflecting vascular responses to cumulative addition of phenylephrine (PE) or dopamine (DOP) were recorded before and after MB addition (2.5 × 10<sup>-4</sup>M final concentration) at the intimal or adventitial surface. Intraluminal addition of MB resulted in strong potentiation of subsequent responses to intimal contractile stimulation using PE or DOP. This effect was not observed when MB was added at the adventitial surface. These results suggest that drug entry site is an important determinant of MB action on vascular responsiveness in the rat tail artery and might account for the divergent results in the literature on the vascular action of MB.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1993
          1993
          23 September 2008
          : 30
          : 5
          : 250-256
          Affiliations
          Laboratoire de Chirurgie Expérimentale, Hôpital Marie-Lannelongue, Le Plessis-Robinson, France
          Article
          159003 J Vasc Res 1993;30:250–256
          10.1159/000159003
          8399985
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Research Paper

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