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      The beta2-microglobulin/cystatin C ratio--a potential marker of post-transplant lymphoproliferative disease.

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          Abstract

          As a consequence of more intensified immunosuppression, post-transplant lymphoproliferative disease (PTLD) is increasingly observed in patients after solid-organ transplantation. Beta2-microglobulin, a low-molecular weight protein (MW 11.8 kDa), is produced by all nucleated cells as part of the HLA complex. Its serum concentration is directly correlated with prognosis in patients with lymphatic neoplasms. Like other low-molecular weight proteins, beta2-microglobulin is eliminated by glomerular filtration. This complicates its use as a tumor marker in renal insufficiency. Cystatin C, a low-molecular weight protein of 13.3 kDa, is a new marker of kidney function largely unaffected by extrarenal disease. We, therefore, sought to assess the potential of the beta2-microglobulin/cystatin C ratio (beta2M/Cys) as a marker of lymphoproliferation.

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          Author and article information

          Journal
          Clin. Nephrol.
          Clinical nephrology
          0301-0430
          0301-0430
          Dec 2002
          : 58
          : 6
          Affiliations
          [1 ] Medical Center of Bonn University, The Children's Hospital, Bonn, Germany. bokenkamp@compuserve.com
          Article
          12508963
          4c7262ef-391d-4fb5-bf8c-973ff7f03890
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