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      Evolution of myoglobin.

      Cellular and Molecular Life Sciences
      Amino Acid Sequence, Animals, Eukaryotic Cells, Evolution, Molecular, Hemoglobins, genetics, Humans, Invertebrates, Models, Molecular, Molecular Sequence Data, Myoglobin, chemistry, physiology, Oxygen, metabolism, Phylogeny, Prokaryotic Cells, Protein Conformation, Sequence Homology, Amino Acid, Vertebrates

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          Abstract

          The distribution, physiological function, amino acid sequence and gene structure of myoglobin and myoglobin-like proteins from various taxa are summarized, and their evolution is discussed. Although it has long been thought that all haemoglobins and myoglobins have evolved from a common ancestral gene, the knowledge presently accumulated about the structures of these proteins suggests that there may be three distinct origins: a 'universal globin', a 'compact globin' and an 'IDO-like globin'.

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