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MHC Restriction of V-V Interactions in Serum IgG

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      Abstract

      According to Jerne's idiotypic network hypothesis, the adaptive immune system is regulated by interactions between the variable regions of antibodies, B cells, and T cells.1 The symmetrical immune network theory2,3 is based on Jerne's hypothesis, and provides a basis for understanding many of the phenomena of adaptive immunity. The theory includes the postulate that the repertoire of serum IgG molecules is regulated by T cells, with the result that IgG molecules express V region determinants that mimic V region determinants present on suppressor T cells. In this paper we describe rapid binding between purified murine serum IgG of H-2b and H-2d mice and serum IgG from the same strain and from MHC-matched mice, but not between serum IgG preparations of mice with different MHC genes. We interpret this surprising finding in terms of a model in which IgG molecules are selected to have both anti-anti-(self MHC class II) and anti-anti-anti-(self MHC class II) specificity.

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      Journal
      04 March 2014
      1403.1551

      http://arxiv.org/licenses/nonexclusive-distrib/1.0/

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      q-bio.CB

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