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      An Experimental Study of the Interleukin 1 Levels in Aqueous Humor after Intraocular Lens Implantation

      ,

      Ophthalmologica

      S. Karger AG

      Intraocular Lens, Interleukin 1 (IL-1)

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          Abstract

          This paper studies the interleukin 1 (IL-1) levels in aqueous humor after intraocular lens (IOL) implantation in rabbits and discusses the effect of IL-1 on postoperative anterior ocular inflammation. Twenty-seven pigmented rabbits were divided into three groups: in the first group, the IOL were placed in the capsular bag after lens extraction; in the second, the lenses of rabbits were removed without IOL implantation, and the third served as the control group without surgical intervention. On the 1st, 3rd, 7th and 14th postoperative days, aqueous humor samples were obtained. MTT colorimetry was employed to detect the presence of IL-1. The data were closely studied by means of analysis of variance with SAS software. The IL-1 level in aqueous humor reached its maximum on the 14th postoperative day in the IOL-implanted group, and the IL-1 levels in aqueous humor were significantly higher (p < 0.05) on the 1st, 3rd, 7th and 14th days postoperatively in the IOL-implanted group than in the non-surgical-intervention group and extracapsular-lens-extracted group. The result suggests that there is a physical relation to the IOL itself, a relation that induces the secretion of IL-1. The result, however, is also likely to have merely come from the mechanical factors related to the presence of the IOL itself.

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          Most cited references 4

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          Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro.

          Clinical and experimental evidence suggests that shock, arthritis, osteoporosis, colitis, leukemia, diabetes, wasting and atherosclerosis are mediated, in part, by interleukin 1 (IL-1). Inhibition of this cytokine has been a strategy for studying disease and for new drug development. A naturally-occurring IL-1 inhibitor (IL-1 receptor antagonist, IL-1ra) that blocks binding of IL-1 to its receptors has been cloned and produced in recombinant organisms. IL-1ra reduces the severity of sepsis, colitis, arthritis and diabetes in animals and is presently being tested in humans with arthritis, shock and myelogenous leukemia.
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            Interleukin 1: the first interleukin.

            The name 'interleukin' and the designation of interleukin 1 (IL-1) derived from the Second International Lymphokine Workshop held in Switzerland in 1979. Since then interest in the original interleukin (IL-1) has increased exponentially as measured by the numbers of publications and meetings. The main reasons for this can be seen in the accompanying centrefold. The perception of IL-1 as a biological mediator in every organ system has attracted scientists from widely different backgrounds into this area and a steady succession of important and often surprising insights into IL-1 biology has ensured that interest has been sustained at a high level. This overview of the biology of IL-1 on the tenth anniversary of its turbulent life has been compiled by Franco di Giovine and Gordon Duff. It is of necessity selective and biased towards human IL-1 and begins with some general points (mainly cautionary) as a backdrop to the centrefold.
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              • Record: found
              • Abstract: not found
              • Article: not found

              Tumor necrosis factor in the pathophysiology of infection and sepsis.

               S F Lowry,  Y. Fong (1990)
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                Author and article information

                Journal
                OPH
                Ophthalmologica
                10.1159/issn.0030-3755
                Ophthalmologica
                S. Karger AG
                0030-3755
                1423-0267
                1998
                June 1998
                19 March 1998
                : 212
                : 3
                : 157-159
                Affiliations
                Department of Ophthalmology, 304th Hospital, Trauma Center of Postgraduate Medical College, Beijing, PR China
                Article
                27267 Ophthalmologica 1998;212:157–159
                10.1159/000027267
                9562087
                © 1998 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Tables: 1, References: 27, Pages: 3
                Categories
                Original Paper · Travail original · Originalarbeit

                Vision sciences, Ophthalmology & Optometry, Pathology

                Intraocular Lens, Interleukin 1 (IL-1)

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