Vitamin K(2) selectively induced apoptosis in ovarian TYK-nu and pancreatic MIA PaCa-2 cells out of eight solid tumor cell lines through a mechanism different from geranylgeraniol.

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Abstract

In this study, we examined the effects of vitamin K(2) (menaquinone 4), which has a geranylgeranyl side chain, on various lines of cells derived from human solid tumors and compared them with the effects of geranylgeraniol (GGO).

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Journal

Journal ID (iso-abbrev): J. Cancer Res. Clin. Oncol.

Title: Journal of cancer research and clinical oncology

Publisher: Springer Nature America, Inc

ISSN: 0171-5216

ISSN (Print): 0171-5216

Publication date (Electronic): Jan 2003

Volume: 129

Issue: 1

Affiliations

[1 ] Laboratory of Biological Chemistry, School of Pharmaceutical Sciences, Showa University, Hatanodai, Shinagawaku, Tokyo 142-8555, Japan. imazuto@pharm.showa-u.ac.jp

Article

DOI: 10.1007/s00432-002-0393-7

PubMed ID: 12618894

SO-VID: 4ca2a211-cbe4-44e8-9757-4481baf85594

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