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      Neutrophil and Eosinophil Degranulation during Hemodialysis Are Mediated by the Dialysis Membrane

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          Abstract

          During hemodialysis of heparinized blood without having a patient in the circuit, the serum concentrations of lactoferrin, myeloperoxidase (MPO) and ëosinophil cationic protein (ECP) steadily increased, indicating neutrophil and ëosinophil degranulation. The increments in serum of these granular proteins were more pronounced using plate dialyzers than capillary dialyzers. The release of granule constituents does not seem to reflect merely a sequestration of granulocytes in the dialyzer, since the increase of the serum concentrations of lactic dehydrogenase was very modest. The intracellular contents of lactoferrin, MPO, lysozyme and ECP were reduced after experimental dialysis in the granulocytes isolated from the blood, indicating that the cells in association with degranulation were not entrapped in the dialyzer. The relatively modest increase of the plasma concentrations of lysozyme during experimental hemodialysis, in spite of the reduction of the intracellular content of lysozyme, was explained by the propensity of lysozyme for adhering to the dialysis membrane. Serum samples obtained at different times during dialysis did not induce an enhanced release of granular proteins from isolated granulocytes in vitro. The earlier observed increase during hemodialysis of the serum concentrations of granular proteins in uremic patients can be explained by the dialysis membrane triggering granulocytes to degranulate.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 32
          : 4
          : 329-334
          Affiliations
          Departments of Internal Medicine and Clinical Chemistry, University Hospital, Uppsala, Sweden
          Article
          182874 Nephron 1982;32:329–334
          10.1159/000182874
          6300712
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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