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      Recent advances in asymmetric phase-transfer catalysis.

      Angewandte Chemie (International Ed. in English)
      Catalysis, Crown Ethers, chemistry, Molecular Structure, Onium Compounds, Organic Chemicals, chemical synthesis, Phase Transition, Stereoisomerism

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          Abstract

          The use of chiral nonracemic onium salts and crown ethers as effective phase-transfer catalysts have been studied intensively primarily for enantioselective carbon-carbon or carbon-heteroatom bond-forming reactions under mild biphasic conditions. An essential issue for optimal asymmetric catalysis is the rational design of catalysts for targeted reaction, which allows generation of a well-defined chiral ion pair that reacts with electrophiles in a highly efficient and stereoselective manner. This concept, together with the synthetic versatility of phase-transfer catalysis, provides a reliable and general strategy for the practical asymmetric synthesis of highly valuable organic compounds.

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          Author and article information

          Journal
          17525926
          10.1002/anie.200601737

          Chemistry
          Catalysis,Crown Ethers,chemistry,Molecular Structure,Onium Compounds,Organic Chemicals,chemical synthesis,Phase Transition,Stereoisomerism

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