Hiroyuki Naruse 1 , Junnichi Ishii 1 , Hiroshi Takahashi 2 , Fumihiko Kitagawa 1 , Ryuunosuke Okuyama 3 , Hideki Kawai 3 , Takashi Muramatsu 3 , Masahide Harada 3 , Akira Yamada 3 , Sadako Motoyama 3 , Shigeru Matsui 3 , Mutsuharu Hayashi 4 , Masayoshi Sarai 3 , Eiichi Watanabe 3 , Hideo Izawa 4 , Yukio Ozaki 3
May 25 2017
A modestly elevated circulating D-dimer level may be relevant to coronary artery disease (CAD), but its prognostic value, both independently and in combination with estimated glomerular filtration rate (eGFR), for long-term death has not been fully evaluated in stable CAD patients.Methods and Results:Baseline plasma D-dimer levels and eGFR were measured in 1,341 outpatients (mean age: 65 years) with prior myocardial infarction (MI), coronary revascularization, and/or angiographic evidence of a significant stenosis (>50%) for at least one of the major coronary arteries. Among these patients, 43% had prior MI, 47% had prior coronary revascularization, 41% had multivessel CAD, 14% had paroxysmal or persistent atrial fibrillation, 32% had diabetes, and 32% had chronic kidney disease (eGFR <60 mL/min/1.73 m(2)). D-dimer levels weakly correlated with eGFR (r=-0.25; P<0.0001). During a mean follow-up period of 73 months, there were 124 deaths, including 61 cardiovascular deaths. Multivariate Cox regression analysis identified D-dimer levels (P=0.001) and eGFR (P=0.006) as independent predictors of all-cause death. Adding both D-dimer and eGFR to a baseline model with established risk factors improved the net reclassification (P<0.005) and integrated discrimination improvement (P<0.05) greater than that of any single biomarker or baseline model alone.