2
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Experimental investigation into the effect of compliance of a mock aorta on cardiac performance

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Demand for heart transplants far exceeds supply of donated organs. This is attributed to the high percentage of donor hearts that are discarded and to the narrow six-hour time window currently available for transplantation. Ex-vivo heart perfusion (EVHP) provides the opportunity for resuscitation of damaged organs and extended transplantation time window by enabling functional assessment of the hearts in a near-physiologic state. Present work investigates the fluid mechanics of the ex-vivo flow loop and corresponding impact on cardiac performance. A mechanical flow loop is developed that is analogous to the region of the EVHP system that mimics in-vivo systemic circulation, including the body’s largest and most compliant artery, the aorta. This investigation is focused on determining the effect of mock aortic tubing compliance on pump performance. A custom-made silicone mock aorta was developed to simulate a range of in-vivo conditions and a physiological flow was generated using a commercial ventricular assist device (VAD). Monitored parameters, including pressure, tube distension and downstream velocity, acquired using time-resolved particle imaging velocimetry (PIV), were applied to an unsteady Bernoulli analysis of the flow in a novel way to evaluate pump performance as a proxy for cardiac workload. When compared to the rigid case, the compliant mock aorta case demonstrated healthier physiologic pressure waveforms, steadier downstream flow and reduced energetic demands on the pump. These results provide experimental verification of Windkessel theory and support the need for a compliant mock aorta in the EVHP system.

          Related collections

          Most cited references61

          • Record: found
          • Abstract: not found
          • Article: not found

          Method for the calculation of velocity, rate of flow and viscous drag in arteries when the pressure gradient is known.

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Prosthetic heart valves: selection of the optimal prosthesis and long-term management.

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Role of pulse pressure amplification in arterial hypertension: experts' opinion and review of the data.

                Bookmark

                Author and article information

                Contributors
                Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: ValidationRole: VisualizationRole: Writing – original draft
                Role: Data curationRole: ValidationRole: Writing – review & editing
                Role: Data curationRole: Formal analysisRole: InvestigationRole: ValidationRole: Writing – review & editing
                Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: Writing – review & editing
                Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole: SoftwareRole: SupervisionRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS One
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                12 October 2020
                2020
                : 15
                : 10
                : e0239604
                Affiliations
                [1 ] Department of Biomedical Engineering, University of Alberta, Edmonton, Canada
                [2 ] Prince Mohammad Bin Fahd University, Al-Khobar, Saudi Arabia
                [3 ] Department of Mechanical Engineering, University of Alberta, Edmonton, Canada
                [4 ] Departments of Surgery, Physiology & Biomedical Engineering, University of Alberta, Edmonton, Canada
                Texas A&M University System, UNITED STATES
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Author information
                http://orcid.org/0000-0001-6446-6676
                Article
                PONE-D-20-03379
                10.1371/journal.pone.0239604
                7549783
                33044976
                4cc24473-224a-451c-b06f-7a3ac76f5d0a
                © 2020 Cameron et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 5 February 2020
                : 10 September 2020
                Page count
                Figures: 13, Tables: 1, Pages: 24
                Funding
                Funded by: funder-id http://dx.doi.org/10.13039/501100002790, Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada;
                Award Recipient :
                Funded by: Canadian Foundation for Innovation
                Award Recipient :
                Funded by: Canadian National Transplant Research Program
                Award Recipient :
                Funded by: University Hospital Foundation
                Award Recipient :
                Financial support for this project was provided by the Natural Sciences and Engineering Research Council (NSERC) of Canada (DSN), Canadian Foundation for Innovation (DSN), Canadian National Transplant Research Program (DHF), and University Hospital Foundation (DHF).
                Categories
                Research Article
                Biology and Life Sciences
                Anatomy
                Cardiovascular Anatomy
                Blood Vessels
                Aorta
                Medicine and Health Sciences
                Anatomy
                Cardiovascular Anatomy
                Blood Vessels
                Aorta
                Physical Sciences
                Physics
                Classical Mechanics
                Motion
                Velocity
                Biology and Life Sciences
                Anatomy
                Cardiovascular Anatomy
                Heart
                Medicine and Health Sciences
                Anatomy
                Cardiovascular Anatomy
                Heart
                Medicine and Health Sciences
                Cardiology
                Systole
                Physical Sciences
                Physics
                Classical Mechanics
                Continuum Mechanics
                Fluid Mechanics
                Fluid Dynamics
                Fluid Flow
                Biology and Life Sciences
                Anatomy
                Cardiovascular Anatomy
                Heart
                Cardiac Ventricles
                Medicine and Health Sciences
                Anatomy
                Cardiovascular Anatomy
                Heart
                Cardiac Ventricles
                Medicine and Health Sciences
                Cardiology
                Diastole
                Medicine and Health Sciences
                Vascular Medicine
                Blood Pressure
                Systolic Pressure
                Custom metadata
                All relevant data are within the manuscript.

                Uncategorized
                Uncategorized

                Comments

                Comment on this article