Effect of Selected Antiarrhythmic Drugs on the Superoxide Anion Production by Polymorphonuclear Neutrophils in vitro

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Abstract

The oxygen radicals produced by polymorphonuclear neutrophils (PMN) during ischemia and reperfusion play an important role in the development of arrhythmias. We investigated the influence of selected antiarrhythmic drugs on PMN superoxide anion production. Amiodarone, verapamil and propranolol significantly decreased the stimulated superoxide anion production, which may be an additional mechanism of their antiarrhythmic activity. The fast sodium channel inhibitors lidocaine, procainamide and mexiletine affected neither spontaneous nor stimulated superoxide anion production.

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Author and article information

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1989

Publication date (Print): 1989

Publication date (Electronic): 12 November 2008

Volume: 76

Issue: 4

Pages: 264-269

Affiliations

Academy of Medicine, Institute of Internal Medicine, Department of Intensive Therapy, Poznan, Poland

Article

Publisher ID: 174502 Other ID: Cardiology 1989;76:264–269

DOI: 10.1159/000174502

PubMed ID: 2553259

SO-VID: 4cdb757a-b82e-4b28-88d9-beec6e0d3f83

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 02 November 1988

Date accepted : 07 March 1989

Page count

Pages: 6

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