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      The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease.

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          Abstract

          Oxidative stress plays a key role in the pathogenesis of various diseases. Antioxidants protect the cells and tissues from oxidative stress by scavenging free radicals and reactive oxygen species. These antioxidants may be endogenous or exogenous. Plants are considered as potential and powerful exogenous source of antioxidants. Astragalus species (spp.), especially Astragalus membranaceus, have a long history of medicinal use in traditional Chinese medicine. Specifically, constituents of the dried roots of Astragalus spp. (Radix Astragali) provide significant protection against heart, brain, kidney, intestine, liver and lung injury in various models of oxidative stress-related disease. Different isolated constituents of Astragalus spp., such as astragalosides, flavonoids and polysaccharides also displayed significant prevention of tissue injury via antioxidant mechanisms. In this article, the antioxidant benefits of Astragalus spp. and its isolated components in protecting tissues from injury are reviewed, along with identification of the various constituents that possess antioxidant activity.

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          Author and article information

          Journal
          Curr Drug Targets
          Current drug targets
          1873-5592
          1389-4501
          2016
          : 17
          : 12
          Affiliations
          [1 ] Centre for Kidney Disease Research, School of Medicine, The University of Queensland, Translational Research Institute, Kent Street, Woolloongabba, Brisbane 4102, Australia. g.gobe@uq.edu.au.
          Article
          CDT-EPUB-70189
          10.2174/1389450116666150907104742
          26343107
          4ce7b4f1-8f44-4b79-8363-55ca930a2a1d
          History

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