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      Association of decreased mRNA expression of multidrug and toxin extrusion protein 1 in peripheral blood cells with the development of flutamide-induced liver injury.

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          Abstract

          The anti-prostate cancer drug flutamide occasionally causes hepatotoxicity, and predictive biomarkers of flutamide-induced liver injury (FILI) are needed to improve safety of this drug. The aim of this prospective study was to identify such a biomarker by analyzing peripheral blood samples from patients before flutamide therapy.

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          Author and article information

          Journal
          Cancer Chemother. Pharmacol.
          Cancer chemotherapy and pharmacology
          1432-0843
          0344-5704
          Jun 2015
          : 75
          : 6
          Affiliations
          [1 ] Department of Urology, Jichi Medical University, Shimotsuke, Japan.
          Article
          10.1007/s00280-015-2743-6
          25862351
          4d0ca5df-1ae4-4e06-8264-efd2dba0d4e9
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