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      Association of Time From Stroke Onset to Groin Puncture With Quality of Reperfusion After Mechanical Thrombectomy : A Meta-analysis of Individual Patient Data From 7 Randomized Clinical Trials

      Author(s): 1 , 2 , 3 , 4 , 1 , 5 , 6 , 7 , 8 , 9 , 5 , 10 , 7 , 10 , 11 , 12 , 2 , 8 , 13 , 7 , 3 , 6 , 7 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 10 , 23 , 24 , 25 , 26 , 27 , 28 , 16 , 2 , 29 , for the HERMES Trialists Collaboration
      Publication date (Electronic):
      Journal: JAMA Neurology
      Publisher: American Medical Association (AMA)

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          Abstract

          Reperfusion is a key factor for clinical outcome in patients with acute ischemic stroke (AIS) treated with endovascular thrombectomy (EVT) for large-vessel intracranial occlusion. However, data are scarce on the association between the time from onset and reperfusion results.

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          Neutrophil extracellular traps in ischemic stroke thrombi.

          Frederik Denorme, Elodie Laridan, Olivier François … (2017)
          Neutrophil extracellular traps (NETs) have been shown to promote thrombus formation. Little is known about the exact composition of thrombi that cause ischemic stroke. In particular, no information is yet available on the presence of NETs in cerebral occlusions. Such information is, however, essential to improve current thrombolytic therapy with tissue plasminogen activator (t-PA). This study aimed at investigating the presence of neutrophils and more specifically NETs in ischemic stroke thrombi.
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            Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke

            Célina Ducroux, Lucas Di Meglio, Stéphane Loyau … (2018)
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              ADAPT FAST study: a direct aspiration first pass technique for acute stroke thrombectomy.

              Michael Dewan, Maxim Mokin, Steve Quarfordt … (2014)
              The development of new revascularization devices has improved recanalization rates and time, but not clinical outcomes. We report a prospectively collected clinical experience with a new technique utilizing a direct aspiration first pass technique with large bore aspiration catheter as the primary method for vessel recanalization.
              Article 0 comments Cited 106 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: JAMA Neurology
                Abbreviated Title: JAMA Neurol
                Publisher: American Medical Association (AMA)
                ISSN (Print): 2168-6149
                Publication date (Electronic): January 22 2019
                Affiliations
                [1 ]Centre Hospitalier Universitaire de Nantes, Nantes Cedex, France
                [2 ]University of Calgary, Calgary, Alberta, Canada
                [3 ]University of California, Los Angeles Medical Center, Los Angeles
                [4 ]University of Glasgow, Glasgow, Scotland
                [5 ]State University of New York at Buffalo
                [6 ]Erasmus MC, University Medical Center, Rotterdam, the Netherlands
                [7 ]Academic Medical Center Amsterdam, Amsterdam, the Netherlands
                [8 ]Maastricht University Medical Center, Maastricht, the Netherlands
                [9 ]University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
                [10 ]The Royal Melbourne Hospital, Victoria, Australia
                [11 ]University Hospital of Montpellier, Montpellier, France
                [12 ]The Florey Institute of Neuroscience and Mental Health, Parkville, Australia
                [13 ]Division of Neurosurgery, Department of Surgery, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
                [14 ]University Hospital of Poitiers, Poitiers, France
                [15 ]Department Radiology, MC Haaglanden, Leidschendam, the Netherlands
                [16 ]Hopital Saint Anne, University Paris-Descartes, Paris, France
                [17 ]Department of Neuroradiology, Royal Victoria Hospital, Belfast, Belfast, Ireland
                [18 ]Altair Biostatistics, Mooresville, North Carolina
                [19 ]Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France
                [20 ]University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
                [21 ]Abington and Jefferson Health, Abington, Pennsylvania
                [22 ]University of Duisburg-Essen, Duisburg-Essen, Germany
                [23 ]Oxford University Hospitals National Health Services Foundation trust and University of Oxford, Oxford, England
                [24 ]Hospital Vall d'Hebron, Barcelona, Spain
                [25 ]Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, England
                [26 ]Department of Clinical Neuroscience, Central Clinical School, Monash University and The Alfred Hospital, Melbourne, Australia
                [27 ]Hospital Clinic of Barcelona, Barcelona, Spain
                [28 ]Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
                [29 ]University of Lorraine, and University Hospital of Nancy, Nancy, France
                Article
                DOI: 10.1001/jamaneurol.2018.4510
                PMC ID: 6459219
                PubMed ID: 30667465
                SO-VID: 4d1efc2d-dbf4-451f-9f58-e77a537c52f2
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