OCT angiography analysis of retinal vessel density in primary open-angle glaucoma with and without Tafluprost therapy

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Abstract

Background

Primary open-angle glaucoma (POAG) is a progressive neurodegenerative disease which leads to irreversible blindness. An elevated intraocular pressure (IOP) is considered to be the main risk factor for the disease progression. It is known that retinal blood flow is altered in POAG eyes. Tafluprost, a prostaglandin analogue which lowers the IOP, has shown to also improve the retinal blood flow in animals.

Methods

The current study therefore evaluated the retinal vessel density in the peripapillary and macular region of POAG patients with normal IOP treated with topical Tafluprost ( n = 20) compared to surgically treated patients with normal IOP ( n = 22) using optical coherence tomography angiography (OCT-A). The retinal flow density was obtained after binarisation and evaluated in five sectors.

Results

There was a significantly higher peripapillary flow density in all sectors in Tafluprost treated eyes when compared to post-surgery eyes. The flow density in the inferior sector of the superficial plexus in the macular region was also significantly higher in the Tafluprost group.

Conclusions: These results indicate that Tafluprost not only lowers IOP, but may also enhance retinal blood flow in POAG patients with a normal IOP.

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Most cited references 47

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The pathophysiology and treatment of glaucoma: a review.

Robert N. Weinreb, Tin Aung, Felipe Medeiros (2014)

Glaucoma is a worldwide leading cause of irreversible vision loss. Because it may be asymptomatic until a relatively late stage, diagnosis is frequently delayed. A general understanding of the disease pathophysiology, diagnosis, and treatment may assist primary care physicians in referring high-risk patients for comprehensive ophthalmologic examination and in more actively participating in the care of patients affected by this condition. To describe current evidence regarding the pathophysiology and treatment of open-angle glaucoma and angle-closure glaucoma. A literature search was conducted using MEDLINE, the Cochrane Library, and manuscript references for studies published in English between January 2000 and September 2013 on the topics open-angle glaucoma and angle-closure glaucoma. From the 4334 abstracts screened, 210 articles were selected that contained information on pathophysiology and treatment with relevance to primary care physicians. The glaucomas are a group of progressive optic neuropathies characterized by degeneration of retinal ganglion cells and resulting changes in the optic nerve head. Loss of ganglion cells is related to the level of intraocular pressure, but other factors may also play a role. Reduction of intraocular pressure is the only proven method to treat the disease. Although treatment is usually initiated with ocular hypotensive drops, laser trabeculoplasty and surgery may also be used to slow disease progression. Primary care physicians can play an important role in the diagnosis of glaucoma by referring patients with positive family history or with suspicious optic nerve head findings for complete ophthalmologic examination. They can improve treatment outcomes by reinforcing the importance of medication adherence and persistence and by recognizing adverse reactions from glaucoma medications and surgeries.

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The impact of ocular blood flow in glaucoma.

Josef Flammer, Selim Orgül, Vital P. Costa … (2002)

Two principal theories for the pathogenesis of glaucomatous optic neuropathy (GON) have been described--a mechanical and a vascular theory. Both have been defended by various research groups over the past 150 years. According to the mechanical theory, increased intraocular pressure (IOP) causes stretching of the laminar beams and damage to retinal ganglion cell axons. The vascular theory of glaucoma considers GON as a consequence of insufficient blood supply due to either increased IOP or other risk factors reducing ocular blood flow (OBF). A number of conditions such as congenital glaucoma, angle-closure glaucoma or secondary glaucomas clearly show that increased IOP is sufficient to lead to GON. However, a number of observations such as the existence of normal-tension glaucoma cannot be satisfactorily explained by a pressure theory alone. Indeed, the vast majority of published studies dealing with blood flow report a reduced ocular perfusion in glaucoma patients compared with normal subjects. The fact that the reduction of OBF often precedes the damage and blood flow can also be reduced in other parts of the body of glaucoma patients, indicate that the hemodynamic alterations may at least partially be primary. The major cause of this reduction is not atherosclerosis, but rather a vascular dysregulation, leading to both low perfusion pressure and insufficient autoregulation. This in turn may lead to unstable ocular perfusion and thereby to ischemia and reperfusion damage. This review discusses the potential role of OBF in glaucoma and how a disturbance of OBF could increase the optic nerve's sensitivity to IOP.

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Rectangular Confidence Regions for the Means of Multivariate Normal Distributions

Zbyněk Šidák (1967)

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Author and article information

Contributors

Hannah Weindler: ha.weindler@uke.de

Journal

Journal ID (nlm-ta): BMC Ophthalmol

Journal ID (iso-abbrev): BMC Ophthalmol

Title: BMC Ophthalmology

Publisher: BioMed Central (London )

ISSN (Electronic): 1471-2415

Publication date (Electronic): 12 November 2020

Publication date PMC-release: 12 November 2020

Publication date Collection: 2020

Volume: 20

Electronic Location Identifier: 444

Affiliations

GRID grid.13648.38, ISNI 0000 0001 2180 3484, Department of Ophthalmology, , University Medical Center Hamburg-Eppendorf, ; Martinistraße 52, 20246 Hamburg, Germany

Article

Publisher ID: 1707

DOI: 10.1186/s12886-020-01707-3

PMC ID: 7663898

PubMed ID: 33183272

SO-VID: 4d224b5c-00e8-4c49-9cc5-46315f25e215

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 2 May 2020

Date accepted : 27 October 2020

Custom metadata

ScienceOpen disciplines: Ophthalmology & Optometry

Keywords: primary open-angle glaucoma,optical coherence tomography angiography,tafluprost,retinal flow density,optic nerve head,macular region

Data availability:

ScienceOpen disciplines: Ophthalmology & Optometry

Keywords: primary open-angle glaucoma, optical coherence tomography angiography, tafluprost, retinal flow density, optic nerve head, macular region

OCT angiography analysis of retinal vessel density in primary open-angle glaucoma with and without Tafluprost therapy

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Abstract

Background

Methods

Results

Related collections

Karger: Ophthalmology

Most cited references 47

The pathophysiology and treatment of glaucoma: a review.

The impact of ocular blood flow in glaucoma.

Rectangular Confidence Regions for the Means of Multivariate Normal Distributions

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