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      The Potential for a Novel Pure Anti-Oestrogen

      Hormone Research in Paediatrics

      S. Karger AG

      Pure anti-oestrogen, ICI 164,384, Chemistry, Pharmacology, Mode of action

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          ICI 164,384 is a novel agent, which has all the characteristics of a pure anti-oestrogen in preclinical studies. It completely inhibited oestradiol or tamoxif en-induced uterine growth in immature rats. In intact rats, ICI 164,384 produced a reduction in uterine weight, almost equivalent to that in ovariectomised rats. ICI 164,384 also demonstrated a peripherally selective action in intact rats. ICI 164,384 has a high affinity for the oestrogen receptor and was more effective than tamoxifen in blocking proliferation of MCF-7 human breast cancer cells. Extrapolation of these observations to the therapy of breast cancer would imply that a pure anti-oestrogen might provide additional benefit, compared with Nolvadex, in terms of onset, duration or completeness of response.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 32
          : Suppl 1
          : 257-260
          ICI Pharmaceuticals, Macclesfield, Cheshire, UK
          181359 Horm Res 1989;32:257–260
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 4
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