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      Autism: a transdiagnostic, dimensional, construct of reasoning?

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          Abstract

          The concept of autism has changed across time, from the Bleulerian concept, which defined it as one of several symptoms of dementia praecox, to the present‐day concept representing a pervasive development disorder. The present theoretical contribution to this special issue of EJN on autism introduces new theoretical ideas and discusses them in light of selected prior theories, clinical examples, and recent empirical evidence. The overall aim is to identify some present challenges of diagnostic practice and autism research and to suggest new pathways that may help direct future research. Future research must agree on the definitions of core concepts such as autism and psychosis. A possible redefinition of the concept of autism may be a condition in which the rationale of an individual's behaviour differs qualitatively from that of the social environment due to characteristic cognitive impairments affecting reasoning. A broad concept of psychosis could focus on deviances in the experience of reality resulting from impairments of reasoning. In this light and consistent with recent empirical evidence, it may be appropriate to redefine dementia praecox as a developmental disorder of reasoning. A future challenge of autism research may be to develop theoretical models that can account for the impact of complex processes acting at the social level in addition to complex neurobiological and psychological processes. Such models could profit from a distinction among processes related to (i) basic susceptibility, (ii) adaptive processes and (iii) decompensating factors involved in the development of manifest illness.

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          Autism and abnormal development of brain connectivity.

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            Die „Autistischen Psychopathen” im Kindesalter

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              Common disorders are quantitative traits.

              After drifting apart for 100 years, the two worlds of genetics - quantitative genetics and molecular genetics - are finally coming together in genome-wide association (GWA) research, which shows that the heritability of complex traits and common disorders is due to multiple genes of small effect size. We highlight a polygenic framework, supported by recent GWA research, in which qualitative disorders can be interpreted simply as being the extremes of quantitative dimensions. Research that focuses on quantitative traits - including the low and high ends of normal distributions - could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits.
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                Author and article information

                Contributors
                boag@regionsjaelland.dk
                Journal
                Eur J Neurosci
                Eur. J. Neurosci
                10.1111/(ISSN)1460-9568
                EJN
                The European Journal of Neuroscience
                John Wiley and Sons Inc. (Hoboken )
                0953-816X
                1460-9568
                25 May 2017
                March 2018
                : 47
                : 6 , THE NEUROBIOLOGICAL BASES OF AUTISM SPECTRUM DISORDERS ( doiID: 10.1111/ejn.2018.47.issue-6 )
                : 515-533
                Affiliations
                [ 1 ] Department of Child and Adolescent Psychiatry Psychiatry Region Zealand Ny Østergade 12 DK‐4000 Roskilde Denmark
                [ 2 ] Faculty of Medical and Health Sciences Department of Clinical Medicine University of Copenhagen Blegdamsvej 3B DK‐2200 Copenhagen N Denmark
                Author notes
                [*] [* ] Correspondence: Bodil Aggernæs, 1Department of Child and Adolescent Psychiatry, Psychiatry Region Zealand as above.

                E‐mail: boag@ 123456regionsjaelland.dk

                Author information
                http://orcid.org/0000-0001-7608-1829
                Article
                EJN13599
                10.1111/ejn.13599
                6084350
                28452080
                4d36adf7-8395-4e8f-b900-5ec56c97e716
                © 2017 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                : 19 December 2016
                : 17 April 2017
                : 19 April 2017
                Page count
                Figures: 2, Tables: 0, Pages: 19, Words: 20417
                Categories
                Special Issue Review
                The Neurobiological Bases of Autism Spectrum Disorders
                Custom metadata
                2.0
                ejn13599
                March 2018
                Converter:WILEY_ML3GV2_TO_NLMPMC version:version=5.4.4 mode:remove_FC converted:09.08.2018

                Neurosciences
                cognitive impairments,psychosis,schizophrenia,stress,vulnerability
                Neurosciences
                cognitive impairments, psychosis, schizophrenia, stress, vulnerability

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