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      Valproic acid (VPA) inhibits the epithelial-mesenchymal transition in prostate carcinoma via the dual suppression of SMAD4.

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          Abstract

          The epithelial-mesenchymal transition (EMT) plays an important role in cancer metastasis. Previous studies have reported that valproic acid (VPA) suppresses prostate carcinoma (PCa) cell metastasis and down-regulates SMAD4 protein levels, which is the key molecule in TGF-β-induced EMT. However, the correlation between VPA and the EMT in PCa remains uncertain.

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          Author and article information

          Journal
          J. Cancer Res. Clin. Oncol.
          Journal of cancer research and clinical oncology
          Springer Nature
          1432-1335
          0171-5216
          Jan 2016
          : 142
          : 1
          Affiliations
          [1 ] Minimally Invasive Urology Center, Shandong Provincial Hospital Affiliated to Shandong University, 9677 Jingshidong Road, Jinan, 250014, China.
          [2 ] Department of Urology, Dongying People's Hospital, Dongying, 257000, China.
          [3 ] Minimally Invasive Urology Center, Shandong Provincial Hospital Affiliated to Shandong University, 9677 Jingshidong Road, Jinan, 250014, China. xqhgege@hotmail.com.
          Article
          10.1007/s00432-015-2020-4
          10.1007/s00432-015-2020-4
          26206483
          4d4607fb-03a0-4b9b-a1ba-38ee35a55919
          History

          Epithelial–mesenchymal transition,Valproic acid,SMAD4,Prostate carcinoma

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