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      Early Growth and Neurologic Outcomes of Infants with Probable Congenital Zika Virus Syndrome

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          Abstract

          We report the early growth and neurologic findings of 48 infants in Brazil diagnosed with probable congenital Zika virus syndrome and followed to age 1–8 months. Most of these infants had microcephaly (86.7%) and craniofacial disproportion (95.8%). The clinical pattern included poor head growth with increasingly negative z-scores, pyramidal/extrapyramidal symptoms, and epilepsy.

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          First report of autochthonous transmission of Zika virus in Brazil

          Camila Zanluca, Vanessa de Melo, Ana Mosimann … (2015)
          In the early 2015, several cases of patients presenting symptoms of mild fever, rash, conjunctivitis and arthralgia were reported in the northeastern Brazil. Although all patients lived in a dengue endemic area, molecular and serological diagnosis for dengue resulted negative. Chikungunya virus infection was also discarded. Subsequently, Zika virus (ZIKV) was detected by reverse transcription-polymerase chain reaction from the sera of eight patients and the result was confirmed by DNA sequencing. Phylogenetic analysis suggests that the ZIKV identified belongs to the Asian clade. This is the first report of ZIKV infection in Brazil.
          Article 0 comments Cited 509 times – based on 0 reviews     Review now
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            Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation.

            Giovanny França, Lavinia Schuler-Faccini, Wanderson K. Oliveira … (2016)
            In November, 2015, an epidemic of microcephaly was reported in Brazil, which was later attributed to congenital Zika virus infection. 7830 suspected cases had been reported to the Brazilian Ministry of Health by June 4, 2016, but little is known about their characteristics. We aimed to describe these newborn babies in terms of clinical findings, anthropometry, and survival.
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              Notes from the Field: Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses--Brazil, 2015.

              Roosecelis Brasil Martines, Julu Bhatnagar, M Kelly Keating … (2016)
              Zika virus is a mosquito-borne flavivirus that is related to dengue virus and transmitted primarily by Aedes aegypti mosquitoes, with humans acting as the principal amplifying host during outbreaks. Zika virus was first reported in Brazil in May 2015 (1). By February 9, 2016, local transmission of infection had been reported in 26 countries or territories in the Americas.* Infection is usually asymptomatic, and, when symptoms are present, typically results in mild and self-limited illness with symptoms including fever, rash, arthralgia, and conjunctivitis. However, a surge in the number of children born with microcephaly was noted in regions of Brazil with a high prevalence of suspected Zika virus disease cases. More than 4,700 suspected cases of microcephaly were reported from mid-2015 through January 2016, although additional investigations might eventually result in a revised lower number (2). In response, the Brazil Ministry of Health established a task force to further investigate possible connections between the virus and brain anomalies in infants (3).
              Article 0 comments Cited 166 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Emerg Infect Dis
                Journal ID (iso-abbrev): Emerging Infect. Dis
                Journal ID (publisher-id): EID
                Title: Emerging Infectious Diseases
                Publisher: Centers for Disease Control and Prevention
                ISSN (Print): 1080-6040
                ISSN (Electronic): 1080-6059
                Publication date (Print): November 2016
                Volume: 22
                Issue: 11
                Pages: 1953-1956
                Affiliations
                [1]Federal University of Maranhão, Sao Luis, Maranhão, Brazil (A.A.M. Silva, M.R.C. Ribeiro, M.R.F.C. Branco, R.C.S. Queiroz, M.J.T. Pacheco, V.M.F. Simões, F. Lamy-Filho, Z.C. Lamy, M.T.S.S.B. Alves);
                [2]State Department of Health of Maranhão, Sao Luis, Maranhão (J.S.S. Ganz, P.S. Sousa, M.J.R. Doriqui, F.R.V. da Costa, F.S. Silva, M.A.B. Pacheco)
                Author notes
                Address for correspondence: Antonio Augusto Moura da Silva, Programa de Pos-Graduacao em Saude Coletiva, Universidade Federal do Maranhão, Rua Barao de Itapary, 155, Centro, 65020-070 São Luís, Maranhão, Brasil; email: aamouradasilva@ 123456gmail.com
                Article
                Publisher ID: 16-0956
                DOI: 10.3201/eid2211.160956
                PMC ID: 5088045
                PubMed ID: 27767931
                SO-VID: 4d4c1c83-4544-470d-9923-6c58c23bc511
                History
                Categories
                Subject: Dispatch
                Subject: Dispatch
                Subject: Early Growth and Neurologic Outcomes of Infants with Probable Congenital Zika Virus Syndrome

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: zika virus infection,growth,birthweight,epilepsy,microcephaly,congenital abnormalities,neurologic,outcomes,infants,viruses
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: zika virus infection, growth, birthweight, epilepsy, microcephaly, congenital abnormalities, neurologic, outcomes, infants, viruses

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