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      Triterpene saponins from clematis mandshurica.

      Journal of Natural Products
      Animals, Clematis, chemistry, Cyclooxygenase 2 Inhibitors, isolation & purification, pharmacology, Drugs, Chinese Herbal, Inhibitory Concentration 50, Macrophages, Peritoneal, drug effects, Male, Mice, Mice, Inbred C57BL, Molecular Structure, Plant Roots, Plants, Medicinal, Rhizome, Saponins, Triterpenes

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          Abstract

          Four new triterpene saponins, clematomandshurica saponins A-D (1-4), together with three known saponins (5-7) have been isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of their spectroscopic evidence and hydrolysis. Clematomandshurica saponins A and B showed significant inhibitory activity on cyclooxygenase-2 (IC50 = 2.66 and 2.58 microM, respectively).

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