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      Health related quality of life in children with sickle cell disease: A systematic review and meta-analysis.

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          Abstract

          This review had three aims: 1) describe the measures used to assess health-related quality of life (HRQL) in pediatric patients diagnosed with sickle cell disease (SCD); 2) document the biopsychosocial factors related to HRQL in pediatric patients diagnosed with SCD; and 3) complete a meta-analysis comparing HRQL in pediatric patients diagnosed with SCD to healthy controls. Included studies were published in English, quantitatively assessed HRQL as a primary aim, in both SCD and controls, and included participants between 0 and 21 years of age. The final review included 66 articles, with a total of 8642 participants with SCD, 4 months-21 years of age, and 62,458 controls, 5-27 years of age. HRQL was predominately measured using the Pediatric Quality of Life Inventory Generic Core and Sickle Cell Disease Module. Meta-analyses revealed children with SCD had significantly worse HRQL compared to healthy controls (standardized mean difference = -0.93, 95% CI = -1.25, -0.61, p < 0.00001). Worse HRQL was associated with more severe SCD, female sex, and pain. The findings indicate that children with SCD are at risk for worse HRQL compared to their healthy peers and their HRQL may be impacted by several biopsychosocial factors. Future research is needed to examine how sociocultural factors uniquely impact this population and their overall quality of life.

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          Author and article information

          Journal
          Blood Rev
          Blood reviews
          Elsevier BV
          1532-1681
          0268-960X
          Nov 2022
          : 56
          Affiliations
          [1 ] Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada. Electronic address: sandhm@ucalgary.ca.
          [2 ] Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada. Electronic address: hailey.zwicker@ucalgary.ca.
          [3 ] Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada. Electronic address: Caitlin.forbes@albertahealthservices.ca.
          [4 ] Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada.
          [5 ] Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada; Department of Pediatrics, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada. Electronic address: taryn.fay-mcclymont@albertahealthservices.ca.
          [6 ] Department of Psychology, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada. Electronic address: naddley.desire@sickkids.ca.
          [7 ] Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada. Electronic address: greg.guilcher@albertahealthservices.ca.
          [8 ] Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada. Electronic address: Gurpreet.singh@albertahealthservices.ca.
          [9 ] Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada. Electronic address: Michael.leaker@albertahealthservices.ca.
          [10 ] Department of Psychology, Faculty of Arts, University of Calgary, 527 Campus Pl NW, Calgary, AB T2N 4V8, Canada. Electronic address: kyeates@ucalgary.ca.
          [11 ] Department of Psychology, Faculty of Arts, University of Calgary, 527 Campus Pl NW, Calgary, AB T2N 4V8, Canada. Electronic address: kbrussel@ucalgary.ca.
          [12 ] Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada. Electronic address: sara.cho@ucalgary.ca.
          [13 ] Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada. Electronic address: tessa.carrels1@ucalgary.ca.
          [14 ] Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada. Electronic address: iqra.rahamatullah@ucalgary.ca.
          [15 ] Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada. Electronic address: Brianna.henry@ucalgary.ca.
          [16 ] Department of Health Sciences, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada. Electronic address: Nicole.dunnewold@ucalgary.ca.
          [17 ] Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada; Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada. Electronic address: fsmschul@ucalgary.ca.
          Article
          S0268-960X(22)00056-X
          10.1016/j.blre.2022.100982
          35659429
          4d682d9b-5f1e-409d-88fa-8e50983ecd2a
          History

          Sickle cell disease,Pre-transplant,Pediatric,Health-related quality of life

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