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      Primary Varicose Veins and HLA

      , ,

      Journal of Vascular Research

      S. Karger AG

      Varicose veins, HLA antigens, HLA-B7, Heredity

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          Abstract

          138 patients with primary varices of the lower extremities were typed in two independent studies for 41 HLA antigens A, B, C, and their frequencies were compared to those in controls. In both studies, the patients showed higher frequency of HLA-B7 (36.2 vs. 23.4%, relative risk 1.86, p = 0.0013) and lower frequencies of HLA- Awl9 (9.4 vs. 25.0%, relative risk 0.312, p = 0.00006), Cw5 (0.7 vs. 9.8%, relative risk 0.067, p = 0.0001) and Cw6 (7.3 vs. 27.0%, relative risk 0.212, p = 0.00003). These differences were most pronounced in patients whose fathers also suffered from primary varices. No relationship was found between HLA antigens and the sex of the patients or the age at the onset of varices.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1983
          1983
          19 September 2008
          : 20
          : 2
          : 99-104
          Affiliations
          Cardiovascular Research Center (Head: Dr. J, Fabian) of the Institute for Clinical and Experimental Medicine (Director: Academician P. Málek), Prague, Czechoslovakia
          Article
          158463 Blood Vessels 1983;20:99–104
          10.1159/000158463
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Research Paper

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