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      Call for Papers: Green Renal Replacement Therapy: Caring for the Environment

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      Activation of Epidermal Growth Factor Receptor in the Early Phase after Renal Ischemia-Reperfusion in Rat

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          Abstract

          In order to estimate a regenerative response in the early phase after renal ischemia-reperfusion in rat, we examined the time course of the activation of epidermal growth factor receptor (EGFR) as a response of signal transduction pathway after 45 min ischemia in kidney. The activation of EGFR was observed 5–30 min after the start of reperfusion. Simultaneously, superoxide anion/hydrogen peroxide generated in the mitochondrial fraction was elevated during the same period. On the other hand, the level of EGF decreased in a time-dependent manner. These results suggested that superoxide anion/hydrogen peroxide generated during the ischemia-reperfusion other than EGF could act as an activator for the EGFR. In summary, the activation of EGFR is important as a regenerative response at an early stage after the start of reperfusion in ischemic kidney.

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          Comparative study on factors regulating the level of oxidative stress toward pulmonary nuclei in two different strains of mice

          Yano Tomohiro, Ishikawa Gaku, Ichikawa Tomio (1994)
          Article 0 comments Cited 1 times – based on 0 reviews     Review now
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            Author and article information

            Journal
            Journal ID (publisher-id): NEF
            Journal ID (nlm-ta): Nephron
            Journal ID (doi): 10.1159/issn.1660-8151
            Title: Nephron
            Publisher: S. Karger AG
            ISSN (Print): 1660-8151
            ISSN (Electronic): 2235-3186
            Publication date Subscription-year: 1999
            Publication date (Print): 1999
            Publication date (Electronic): 10 February 1999
            Volume: 81
            Issue: 2
            Pages: 230-233
            Affiliations
            aDivision of Applied Food Research, National Institute of Health and Nutrition, bMinami-Ikebukuro Clinic, and cDepartment of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
            Article
            Publisher ID: 45281 Other ID: Nephron 1999;81:230–233
            DOI: 10.1159/000045281
            PubMed ID: 9933760
            SO-VID: 4d95cb59-02b5-4ef5-a939-0c15c79fed65
            Copyright © © 1999 S. Karger AG, Basel
            License:

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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            Page count
            Figures: 3, References: 20, Pages: 4
            Categories
            Subject: Original Paper

            ScienceOpen disciplines: Cardiovascular Medicine,Nephrology
            Keywords: Epidermal growth factor receptor,Active oxygen,Ischemia-reperfusion,Acute renal failure
            Data availability:
            ScienceOpen disciplines: Cardiovascular Medicine, Nephrology
            Keywords: Epidermal growth factor receptor, Active oxygen, Ischemia-reperfusion, Acute renal failure

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