19
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis.

      Veterinary Journal (London, England : 1997)
      Animals, Cartilage, Articular, pathology, Cytokines, physiology, Dogs, Horses, Humans, Interleukins, Osteoarthritis, immunology, veterinary, Synovitis, Tumor Necrosis Factor-alpha

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Osteoarthritis (OA) is one of the most common and disabling chronic joint disorders affecting horses, dogs and humans. Synovial inflammation or synovitis is a frequently observed phenomenon in osteoarthritic joints and contributes to the pathogenesis of OA through formation of various catabolic and pro-inflammatory mediators altering the balance of cartilage matrix degradation and repair. Catabolic mediators produced by the inflamed synovium include pro-inflammatory cytokines, nitric oxide, prostaglandin E(2) and several neuropeptides, which further contribute to the pathogenesis of OA by increasing cartilage degradation. Recent studies suggest that substance P, corticotropin-releasing factor, urocortin and vasoactive intestinal peptide may also be involved in OA development, but the precise role of these neuropeptides in the pathogenesis of OA is not known. Since increased production of matrix metalloproteinases by the synovium is stimulated by pro-inflammatory cytokines, future anti-inflammatory therapies should focus on the synovium as a means of controlling subsequent inflammatory damage.

          Related collections

          Author and article information

          Journal
          17911037
          10.1016/j.tvjl.2007.08.013

          Chemistry
          Animals,Cartilage, Articular,pathology,Cytokines,physiology,Dogs,Horses,Humans,Interleukins,Osteoarthritis,immunology,veterinary,Synovitis,Tumor Necrosis Factor-alpha

          Comments

          Comment on this article