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      RoB 2: a revised tool for assessing risk of bias in randomised trials

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          The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials

          Flaws in the design, conduct, analysis, and reporting of randomised trials can cause the effect of an intervention to be underestimated or overestimated. The Cochrane Collaboration’s tool for assessing risk of bias aims to make the process clearer and more accurate
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            GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

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              QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies.

              In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.
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                Author and article information

                Journal
                BMJ
                BMJ
                BMJ
                0959-8138
                1756-1833
                August 28 2019
                : l4898
                Article
                10.1136/bmj.l4898
                31462531
                © 2019

                http://www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy

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