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      Urinary Excretion of Thermostable Kidney Antigen (BE Antigen) in Patients with Various Renal Diseases

      a , a

      Nephron

      S. Karger AG

      Kidney BE antigen, Exposure to chromium, Membranous nephropathy

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          Abstract

          Urine samples of 17 patients with nephropathy were tested with precipitating anti-thermostable-kidney antigen sera (anti-kidney BE antigen), which had been made kidney specific by absorption with diverse tissues. Kidney BE antigen was demonstrated in the concentrated urine of a patient (case I.T.) with membranous nephropathy, in whom membranous nephropathy appeared to be associated with exposure to chromium. Kidney BE antigen was, however, not demonstrated in the concentrated urine from the other 16 patients with nephropathy (chronic glomerulonephritis, 7; acute glomerulonephritis, 3; lupus nephritis, 3; membranous nephropathy, 2; diabetic nephropathy, 1). Kidney BE antigen was localized in the tubular cells but not in the glomeruli, by indirect immunofluorescent staining. Kidney BE antigen was not demonstrated in the glomeruli in case I.T., even after acid elution of the sections. The possible role of kidney BE antigen in the pathogenesis of membranous nephropathy is discussed.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1983
          1983
          03 December 2008
          : 33
          : 3
          : 216-219
          Affiliations
          aClinical Central Laboratory, and b3rd Division of Internal Medicine, Kyoto University Hospital, Kyoto, Japan
          Article
          182945 Nephron 1983;33:216–219
          10.1159/000182945
          6405294
          © 1983 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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