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      Effect of 2-Deoxyglucose on Insulin Secretion in the Rabbit

      ,

      Hormone Research in Paediatrics

      S. Karger AG

      Glucagon, Insulin secretion, 2-Deoxyglucose, Dihydroergotamine, Tolbutamide

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          Abstract

          The intravenous injection of 2-deoxyglucose (2-DG), 0.5 g/kg, in the portal vein of rabbits was not followed by insulin secretion, in spite of the intense hyperglycemia produced by this sugar. Dihydroergotamine (DHE), when administered in amounts of 0.3 mg/kg, prevented the 2-DG-induced hyperglycemia; and in such conditions, a late rise in plasma insulin levels was detected When the rabbits were pretreated with DHE, the administration of 2-DG did not block the insulin release induced by glucose, glucagon or tolbutamide.The significance of these findings is discussed.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1973
          1973
          21 November 2008
          : 4
          : 6
          : 331-339
          Affiliations
          Instituto G. Marañón, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid
          Article
          178321 Horm Res 1973;4:331–339
          10.1159/000178321
          4590571
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
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