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Stress-related impairments in cellular immunity
Ronald Glacer ,
Janice K. Kiecolt-Glacer ,
Julie C. Stout ,
Kathleen L. Tarr ,
Carl E. Speicher ,
Jane E. Holliday
November 1985
November 1985
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Abstract
The percentages of total T-lymphocytes (OKT-3+), helper T-cells (OKT-4+), and suppressor
T-cells (OKT-8+) were significantly lower in blood samples obtained from 40 medical
students during examinations, compared to baseline values obtained 6 weeks earlier.
In addition, the response of T-lymphocytes to stimulation by phytohemagglutinin and
concanavilin A was also significantly lower during examinations, compared to baseline.
Self-report data documented significantly greater distress associated with examinations.
The data have implications for immunosuppressive disorders and stress-related illnesses.