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      Does central obesity reflect "Cushing's disease of the omentum"?

      1 , ,
      Lancet (London, England)
      Elsevier BV

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          Abstract

          Central obesity results in a cluster of metabolic abnormalities contributing to premature death. Glucocorticoids regulate adipose-tissue differentiation, function, and distribution, and in excess, cause central obesity. Glucocorticoid hormone action is, in part, controlled by two isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) which interconverts hormonally active cortisol to inactive cortisone. We studied cortisol metabolism within different adipose tissue depots.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          0140-6736
          0140-6736
          Apr 26 1997
          : 349
          : 9060
          Affiliations
          [1 ] Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK.
          Article
          S0140-6736(96)11222-8
          10.1016/S0140-6736(96)11222-8
          9130942
          4dcdeb83-7348-4d02-9264-fea35043f9d9
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