Tom Bowen , 1 , Marco Cicardi 2 , Henriette Farkas 3 , Konrad Bork 4 , Hilary J Longhurst 5 , Bruce Zuraw 6 , Emel Aygoeren-Pürsün 7 , Timothy Craig 8 , Karen Binkley 9 , Jacques Hebert 10 , Bruce Ritchie 11 , Laurence Bouillet 12 , Stephen Betschel 9 , Della Cogar 13 , 14 , John Dean 15 , Ramachand Devaraj 16 , Azza Hamed 17 , Palinder Kamra 17 , Paul K Keith 18 , Gina Lacuesta 19 , Eric Leith 20 , Harriet Lyons 13 , 21 , Sean Mace 9 , Barbara Mako 13 , 22 , Doris Neurath 23 , Man-Chiu Poon 24 , Georges-Etienne Rivard 25 , Robert Schellenberg 26 , Dereth Rowan 13 , 21 , Anne Rowe 13 , 27 , Donald Stark 26 , Smeeksha Sur 28 , Ellie Tsai 29 , Richard Warrington 30 , Susan Waserman 18 , Rohan Ameratunga 31 , Jonathan Bernstein 32 , Janne Björkander 33 , Kristylea Brosz 13 , 34 , John Brosz 13 , 34 , Anette Bygum 35 , Teresa Caballero 36 , Mike Frank 37 , George Fust 3 , George Harmat 38 , Amin Kanani 26 , Wolfhart Kreuz 7 , Marcel Levi 39 , Henry Li 40 , Inmaculada Martinez-Saguer 7 , Dumitru Moldovan 41 , Istvan Nagy 42 , Erik W Nielsen 43 , Patrik Nordenfelt 44 , Avner Reshef 45 , Eva Rusicke 7 , Sarah Smith-Foltz 46 , Peter Späth 47 , Lilian Varga 3 , Zhi Yu Xiang 48
28 July 2010
We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angioedema: a current state-of-the-art review: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema.
To update the International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema (circa 2010).
The Canadian Hereditary Angioedema Network (CHAEN)/Réseau Canadien d'angioédème héréditaire (RCAH) http://www.haecanada.com and cosponsors University of Calgary and the Canadian Society of Allergy and Clinical Immunology (with an unrestricted educational grant from CSL Behring) held our third Conference May 15th to 16th, 2010 in Toronto Canada to update our consensus approach. The Consensus document was reviewed at the meeting and then circulated for review.
This manuscript is the 2010 International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema that resulted from that conference.
Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches including quality of life and cost benefit analyses, followed by large head-to-head clinical trials and then evidence-based guidelines and standards for HAE disease management.