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      • Record: found
      • Abstract: found
      • Article: found

      Veränderungen der Glutathionperoxidaseaktivität in Augengeweben von Emory-Mäusen in Abhängigkeit von Lebensalter und Kataraktstatus

      research-article
      Author(s): a , b
      Publication date (Electronic):
      Journal: Ophthalmologica
      Publisher: S. Karger AG
      Keywords: Glutathione peroxidase, Cataract, Emory mouse, Antioxidant enzymes, Eye tissues

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          Abstract

          The relationship between the activity of the antioxidant defense enzyme glutathione peroxidase (GSH-PX) and the degree of cataract (lens opacity) was examined in 14 Emory mice at the age of 2, 7 and 10 months. Significant decreases in specific GSH-PX activity (mU/mg wet tissue) in the lens as well as in the residual eye tissue were found between 2 and 10 months of age, showing a highly significant correlation of this decrease (r = 0.590, p ∼ 0.001) with the increasing degree of turbidity of the lenses. The results are discussed with regard to the changes of antioxidant mechanisms during cataractogenesis and aging. The role of the maintenance of an optimal level of GSH-PX and other well-known antioxidants (enzymes, vitamins, trace elements including iodide) for a delay of cataractogenesis is pointed out.

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          Author and article information

          Journal
          Journal ID (publisher-id): OPH
          Journal ID (nlm-ta): Ophthalmologica
          Journal ID (doi): 10.1159/issn.0030-3755
          Title: Ophthalmologica
          Publisher: S. Karger AG
          ISSN (Print): 0030-3755
          ISSN (Electronic): 1423-0267
          Publication date Subscription-year: 1994
          Publication date (Print): 1994
          Publication date (Electronic): 01 April 2010
          Volume: 208
          Issue: 1
          Pages: 5-9
          Affiliations
          aAugenabteilung und bPhysiologische Abteilung des Paracelsus-Institutes des Landes Oberösterreich, Bad Hall, Österreich
          Article
          Publisher ID: 310440 Other ID: Ophthalmologica 1994;208:5–9
          DOI: 10.1159/000310440
          PubMed ID: 8145988
          SO-VID: 4ddc8dc4-17a5-4bfa-b391-314e6843bf24
          Copyright © © 1994 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 05 April 1993
          Date accepted : 19 August 1993
          Page count
          Pages: 5
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Eye tissues,Glutathione peroxidase,Cataract,Antioxidant enzymes,Emory mouse
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Eye tissues, Glutathione peroxidase, Cataract, Antioxidant enzymes, Emory mouse

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