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      Veränderungen der Glutathionperoxidaseaktivität in Augengeweben von Emory-Mäusen in Abhängigkeit von Lebensalter und Kataraktstatus

      a , b

      Ophthalmologica

      S. Karger AG

      Glutathione peroxidase, Cataract, Emory mouse, Antioxidant enzymes, Eye tissues

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          Abstract

          The relationship between the activity of the antioxidant defense enzyme glutathione peroxidase (GSH-PX) and the degree of cataract (lens opacity) was examined in 14 Emory mice at the age of 2, 7 and 10 months. Significant decreases in specific GSH-PX activity (mU/mg wet tissue) in the lens as well as in the residual eye tissue were found between 2 and 10 months of age, showing a highly significant correlation of this decrease (r = 0.590, p ∼ 0.001) with the increasing degree of turbidity of the lenses. The results are discussed with regard to the changes of antioxidant mechanisms during cataractogenesis and aging. The role of the maintenance of an optimal level of GSH-PX and other well-known antioxidants (enzymes, vitamins, trace elements including iodide) for a delay of cataractogenesis is pointed out.

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          Author and article information

          Journal
          OPH
          Ophthalmologica
          10.1159/issn.0030-3755
          Ophthalmologica
          S. Karger AG
          0030-3755
          1423-0267
          1994
          1994
          01 April 2010
          : 208
          : 1
          : 5-9
          Affiliations
          aAugenabteilung und bPhysiologische Abteilung des Paracelsus-Institutes des Landes Oberösterreich, Bad Hall, Österreich
          Article
          310440 Ophthalmologica 1994;208:5–9
          10.1159/000310440
          8145988
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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