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      Sympathoadrenal System and Renal Response to Endotoxin in the Primate

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      Nephron

      S. Karger AG

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          Abstract

          The primary purpose of the present study was to correlate the activity of the sympathoadrenal system with the hemodynamic response of the primate kidney to endotoxin. Sooty Mangabey and Rhesus monkeys were anesthetized, and the left kidney of each animal was exposed through a retroperitoneal approach. Renal venous blood was drained into a reservoir for blood flow measurement. Plasma catecholamines were determined by a fluorometric trihydroxyindole procedure. Monkeys not given endotoxin showed relatively constant renal hemodynamic parameters for two hours. In monkeys administered endotoxin, mean renal artery pressure decreased from 118 to 49 mm Hg, blood flow fell from 4.6 to 1.6ml/min/g, and renal vascular resistance significantly increased. Renal denervation reduced renal vasoconstriction after endotoxin. Plasma catecholamine levels were not higher than those of the controls. Our data suggest that renal vasoconstriction is not due to circulating catecholamines, but occurs mainly as a result of sympathetic stimulation. Autoregulation was not present prior to endotoxin, and renal pressure-flow relationships were unaltered during the post-endotoxin period.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1967
          1967
          26 November 2008
          : 4
          : 6
          : 394-404
          Affiliations
          Veterans Administration Hospital and Civil Aeromedical Research Institute, Veterans Administration Hospital, Research Services, Oklahoma City, Okla.
          Article
          179598 Nephron 1967;4:394–404
          10.1159/000179598
          4965155
          © 1967 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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