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      Recognizing and Preventing Overexposure to Methylmercury from Fish and Seafood Consumption: Information for Physicians

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          Abstract

          Fish is a valuable source of nutrition, and many people would benefit from eating fish regularly. But some people eat a lot of fish, every day or several meals per week, and thus can run a significant risk of overexposure to methylmercury. Current advice regarding methylmercury from fish consumption is targeted to protect the developing brain and nervous system but adverse health effects are increasingly associated with adult chronic low-level methylmercury exposure. Manifestations of methylmercury poisoning are variable and may be difficult to detect unless one considers this specific diagnosis and does an appropriate test (blood or hair analysis). We provide information to physicians to recognize and prevent overexposure to methylmercury from fish and seafood consumption. Physicians are urged to ask patients if they eat fish: how often, how much, and what kinds. People who eat fish frequently (once a week or more often) and pregnant women are advised to choose low mercury fish.

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          Most cited references38

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          Cognitive Deficit in 7-Year-Old Children with Prenatal Exposure to Methylmercury

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            Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury.

            A cohort of 1022 consecutive singleton births was generated during 1986-1987 in the Faroe Islands. Increased methylmercury exposure from maternal consumption of pilot whale meat was indicated by mercury concentrations in cord blood and maternal hair. At approximately 7 years of age, 917 of the children underwent detailed neurobehavioral examination. Neuropsychological tests included Finger Tapping; Hand-Eye Coordination; reaction time on a Continuous Performance Test; Wechsler Intelligence Scale for Children-Revised Digit Spans, Similarities, and Block Designs; Bender Visual Motor Gestalt Test; Boston Naming Test; and California Verbal Learning Test (Children). Clinical examination and neurophysiological testing did not reveal any clear-cut mercury-related abnormalities. However, mercury-related neuropsychological dysfunctions were most pronounced in the domains of language, attention, and memory, and to a lesser extent in visuospatial and motor functions. These associations remained after adjustment for covariates and after exclusion of children with maternal hair mercury concentrations above 10 microgram(s) (50 nmol/g). The effects on brain function associated with prenatal methylmercury exposure therefore appear widespread, and early dysfunction is detectable at exposure levels currently considered safe.
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              Maternal Fish Consumption, Hair Mercury, and Infant Cognition in a U.S. Cohort

              Fish and other seafood may contain organic mercury but also beneficial nutrients such as n-3 polyunsaturated fatty acids. We endeavored to study whether maternal fish consumption during pregnancy harms or benefits fetal brain development. We examined associations of maternal fish intake during pregnancy and maternal hair mercury at delivery with infant cognition among 135 mother–infant pairs in Project Viva, a prospective U.S. pregnancy and child cohort study. We assessed infant cognition by the percent novelty preference on visual recognition memory (VRM) testing at 6 months of age. Mothers consumed an average of 1.2 fish servings per week during the second trimester. Mean maternal hair mercury was 0.55 ppm, with 10% of samples > 1.2 ppm. Mean VRM score was 59.8 (range, 10.9–92.5). After adjusting for participant characteristics using linear regression, higher fish intake was associated with higher infant cognition. This association strengthened after adjustment for hair mercury level: For each additional weekly fish serving, offspring VRM score was 4.0 points higher [95% confidence interval (CI), 1.3 to 6.7]. However, an increase of 1 ppm in mercury was associated with a decrement in VRM score of 7.5 (95% CI, –13.7 to –1.2) points. VRM scores were highest among infants of women who consumed > 2 weekly fish servings but had mercury levels ≤1.2 ppm. Higher fish consumption in pregnancy was associated with better infant cognition, but higher mercury levels were associated with lower cognition. Women should continue to eat fish during pregnancy but choose varieties with lower mercury contamination.
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                Author and article information

                Journal
                J Toxicol
                JT
                Journal of Toxicology
                Hindawi Publishing Corporation
                1687-8191
                1687-8205
                2011
                13 July 2011
                : 2011
                : 983072
                Affiliations
                1Stony Brook University, 167 Dana Hall, Stony Brook, NY 11794-5000, USA
                2University at Albany, State University of New York, 5 University Place, A217, Rensselaer, NY 12144, USA
                3Institute of Neurotoxicology and Neurological Disorders, 8232 14th Avenue NE, Seattle, WA 98115, USA
                4Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
                5Groth Consulting Services, 75 Clifford Avenue, Pelham, NY 10803, USA
                6California Pacific Medical Center, 2100 Webster Street, San Francisco, CA 94115, USA
                7School of Medicine, Stony Brook University, 4-175 Health Sciences Center, Stony Brook, NY 11794-8430, USA
                Author notes

                Academic Editor: Dietrich Büsselberg

                Article
                10.1155/2011/983072
                3139210
                21785592
                4de48b6c-e3c5-4fe6-b153-4e52736115a5
                Copyright © 2011 Susan M. Silbernagel et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 30 March 2011
                : 27 April 2011
                Categories
                Review Article

                Toxicology
                Toxicology

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