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      Hyperkalemia during Acute Ammonium Chloride Acidosis in Man

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      Nephron

      S. Karger AG

      Hyperkalemia, Metabolic acidosis, Ammonium chloride

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          Abstract

          The relationship between acid base parameters and serum potassium concentration was studied in controls and in patients during acute ammonium chloride-induced metabolic acidosis. Serum potassium was best correlated with serum bicarbonate during control (r = -0.323; p < 0.01) and acidosis (r = -0.437; p < 0.001). The slopes and intercepts were similar in both instances and the combined correlation was highly significant (r =-0.493; p < 0.001). Examination of the 95% joint confidence region revealed that during acidosis serum potassium was rarely above 5.0 mEq/1 when serum bicarbonate was greater than 16 mEq/1. It is probably not sound clinical practice to ascribe hyperkalemia to acute mild metabolic acidosis.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1985
          1985
          04 December 2008
          : 40
          : 1
          : 38-40
          Affiliations
          University of Chicago Nephrology Program, Pritzker School of Medicine, Chicago, Ill., USA
          Article
          183424 Nephron 1985;40:38–40
          10.1159/000183424
          3923378
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 3
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Ammonium chloride, Metabolic acidosis, Hyperkalemia

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