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The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.

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Science (New York, N.Y.)

American Association for the Advancement of Science (AAAS)

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      Abstract

      Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its approximately 20-megabase genome, which contains approximately 6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.

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      Affiliations
      [1 ] Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. bjloftus@tigr.org
      Journal
      Science
      Science (New York, N.Y.)
      American Association for the Advancement of Science (AAAS)
      1095-9203
      0036-8075
      Feb 25 2005
      : 307
      : 5713
      15653466 1103773 10.1126/science.1103773 3520129 NIHMS249964

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