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      Protein structure modeling with MODELLER.

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          Abstract

          Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. This chapter presents an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of similar protocols (correction of protcols) has resulted in models of useful accuracy for domains in more than half of all known protein sequences.

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          Author and article information

          Journal
          Methods Mol Biol
          Methods in molecular biology (Clifton, N.J.)
          Springer Science and Business Media LLC
          1064-3745
          1064-3745
          2008
          : 426
          Affiliations
          [1 ] Department of Biopharmaceutical Sciences and California Institute for Quantitative Biomedical Research, University of California at San Francisco, San Francisco, CA, USA.
          Article
          10.1007/978-1-60327-058-8_8
          18542861
          4e02afaf-5a91-40ec-ac51-1cb618381cbb
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