C-Reactive Protein, Fecal Calprotectin, and Stool Lactoferrin for Detection of Endoscopic Activity in Symptomatic Inflammatory Bowel Disease Patients: A Systematic Review and Meta-Analysis.

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Abstract

Persistent disease activity is associated with a poor prognosis in inflammatory bowel disease (IBD). Therefore, monitoring of patients with intent to suppress subclinical inflammation has emerged as a treatment concept. As endoscopic monitoring is invasive and resource intensive, identification of valid markers of disease activity is a priority. The objective was to evaluate the diagnostic accuracy of C-reactive protein (CRP), fecal calprotectin (FC), and stool lactoferrin (SL) for assessment of endoscopically defined disease activity in IBD.

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Journal

Journal ID (iso-abbrev): Am. J. Gastroenterol.

Title: The American journal of gastroenterology

ISSN (Electronic): 1572-0241

ISSN (Print): 0002-9270

Publication date (Electronic): Jun 2015

Volume: 110

Issue: 6

Affiliations

[1 ] 1] Department of Medicine, University of Western Ontario, London, Ontario, Canada [2] Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia [3] Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada.

[2 ] 1] Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada [2] Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.

[3 ] Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

[4 ] Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada.

[5 ] 1] Department of Medicine, University of Western Ontario, London, Ontario, Canada [2] London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada.

[6 ] 1] Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada [2] Division of Gastroenterology, University of California San Diego, La Jolla, California, USA.

[7 ] 1] Department of Medicine, University of Western Ontario, London, Ontario, Canada [2] Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada [3] Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.

Article

Publisher Item ID: ajg2015120

DOI: 10.1038/ajg.2015.120

PubMed ID: 25964225

SO-VID: 4e17efd4-dd45-4283-bcdc-baf2e3ee2ec5

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