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      Effect of a Long-Acting Somatostatin Derivative SMS 201-995 (Sandostatin) on Glucose Homeostasis in Type I Diabetes mellitus

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          Abstract

          The infusion of natural somatostatin (SRIF) has been able to partially correct postprandial hyperglycemic reactions in insulin-dependent diabetes mellitus (IDDM). SMS 201-995 (Sandostatin) is a long-acting derivative with a growth hormone-suppressive effect 10-60 times more potent than the native peptide. The effect of SMS 201-995 (50 µg s.c.) on glucose control by exogenous insulin has been documented in a series of type I diabetics after stabilization of blood sugar by an artificial pancreas. Inhibition of counterregulatory mechanisms significantly diminished the postprandial hyperglycemia, and insulin requirements, both total and 2 h after meals, were markedly decreased. Also the effect of a single s.c. injection of 100 µg SMS 201-995 on the dawn phenomenon in a patient with poorly adjustable diabetes was investigated. The glucose escape observed during the control night was blocked by SMS 201-995. Thus, the stabilizing action of this peptide on postprandial and nocturnal hyperglycemia in unstable diabetes warrants further studies.

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          Author and article information

          Journal
          Journal ID (publisher-id): HRE
          Journal ID (nlm-ta): Horm Res Paediatr
          Journal ID (doi): 10.1159/issn.1663-2818
          Title: Hormone Research in Paediatrics
          Publisher: S. Karger AG
          ISBN: 978-3-8055-4809-0
          ISBN: 978-3-318-01960-5
          ISSN (Print): 1663-2818
          ISSN (Electronic): 1663-2826
          Publication date Subscription-year: 1988
          Publication date (Print): 1988
          Publication date (Electronic): 28 November 2008
          Volume: 29
          Issue: 2-3
          Pages: 92-94
          Affiliations
          aServicio de Medicina Interna, Centra Ramón y Cajal, Madrid, España; bExperimental Therapeutics Department, Clinical Research, Sandoz AG, Basle, Switzerland
          Article
          Publisher ID: 180977 Other ID: Horm Res 1988;29:92–94
          DOI: 10.1159/000180977
          PubMed ID: 2900205
          SO-VID: 4e1a9354-f9f7-419b-83fe-ffecb577f096
          Copyright © © 1988 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 3
          Categories
          Subject: Somatostatin: Recent Advances in Basic Research and Clinical Applications

          ScienceOpen disciplines: Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Keywords: Counterregulation,Diabetes control,Somatostatin,Dawn phenomenon
          Data availability:
          ScienceOpen disciplines: Endocrinology & Diabetes, Neurology, Nutrition & Dietetics, Sexual medicine, Internal medicine, Pharmacology & Pharmaceutical medicine
          Keywords: Counterregulation, Diabetes control, Somatostatin, Dawn phenomenon

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