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      Effect of a Long-Acting Somatostatin Derivative SMS 201-995 (Sandostatin) on Glucose Homeostasis in Type I Diabetes mellitus

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          The infusion of natural somatostatin (SRIF) has been able to partially correct postprandial hyperglycemic reactions in insulin-dependent diabetes mellitus (IDDM). SMS 201-995 (Sandostatin) is a long-acting derivative with a growth hormone-suppressive effect 10-60 times more potent than the native peptide. The effect of SMS 201-995 (50 µg s.c.) on glucose control by exogenous insulin has been documented in a series of type I diabetics after stabilization of blood sugar by an artificial pancreas. Inhibition of counterregulatory mechanisms significantly diminished the postprandial hyperglycemia, and insulin requirements, both total and 2 h after meals, were markedly decreased. Also the effect of a single s.c. injection of 100 µg SMS 201-995 on the dawn phenomenon in a patient with poorly adjustable diabetes was investigated. The glucose escape observed during the control night was blocked by SMS 201-995. Thus, the stabilizing action of this peptide on postprandial and nocturnal hyperglycemia in unstable diabetes warrants further studies.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          28 November 2008
          : 29
          : 2-3
          : 92-94
          aServicio de Medicina Interna, Centra Ramón y Cajal, Madrid, España; bExperimental Therapeutics Department, Clinical Research, Sandoz AG, Basle, Switzerland
          180977 Horm Res 1988;29:92–94
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 3
          Somatostatin: Recent Advances in Basic Research and Clinical Applications


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