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      NAD+ and sirtuins in aging and disease.

      Trends in Cell Biology
      Aging, metabolism, Animals, Circadian Rhythm, Disease, Humans, Mitochondria, NAD, Sirtuins

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          Abstract

          Nicotinamide adenine dinucleotide (NAD(+)) is a classical coenzyme mediating many redox reactions. NAD(+) also plays an important role in the regulation of NAD(+)-consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 ectoenzymes. NAD(+) biosynthesis, particularly mediated by nicotinamide phosphoribosyltransferase (NAMPT), and SIRT1 function together to regulate metabolism and circadian rhythm. NAD(+) levels decline during the aging process and may be an Achilles' heel, causing defects in nuclear and mitochondrial functions and resulting in many age-associated pathologies. Restoring NAD(+) by supplementing NAD(+) intermediates can dramatically ameliorate these age-associated functional defects, counteracting many diseases of aging, including neurodegenerative diseases. Thus, the combination of sirtuin activation and NAD(+) intermediate supplementation may be an effective antiaging intervention, providing hope to aging societies worldwide. Copyright © 2014 Elsevier Ltd. All rights reserved.

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          Author and article information

          Journal
          24786309
          4112140
          10.1016/j.tcb.2014.04.002

          Chemistry
          Aging,metabolism,Animals,Circadian Rhythm,Disease,Humans,Mitochondria,NAD,Sirtuins
          Chemistry
          Aging, metabolism, Animals, Circadian Rhythm, Disease, Humans, Mitochondria, NAD, Sirtuins

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