Acute effects of three club drugs on the striatum of rats: evaluation by quantitative autoradiography with [18F]FDOPA.

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Abstract

In this work, we used quantitative autoradiography to study the acute effect of cocaine, methamphetamine, and ketamine on the uptake of [(18)F]FDOPA in the striatum of rats. Drugs were treated 0.5 h before (pre-treated), and 1.5 h after (post-treated) [(18)F]FDOPA injections, rats were then sacrificed at 2 h post [(18)F]FDOPA injections to determine the striatum/frontal cortex binding ratios in the striatum. The ratios were lower in the post-treated groups than those of the pre-treated groups, suggesting a net effect of inhibition of trapping of the tracer. The order of uptake inhibition is: ketamine>methamphetamine>cocaine.

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Journal

Journal ID (iso-abbrev): Appl Radiat Isot

Title: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

ISSN (Electronic): 1872-9800

ISSN (Print): 0969-8043

Publication date (Electronic): Jul 2013

Volume: 77

Affiliations

[1 ] Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan.

Article

Publisher Item ID: S0969-8043(13)00181-4

DOI: 10.1016/j.apradiso.2013.03.091

PubMed ID: 23587698

SO-VID: 4e3ad28c-1d97-42e5-86f6-20c32fe9e270

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