Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

A DNA-based method for rationally assembling nanoparticles into macroscopic materials.

Nature

chemistry, Temperature, ultrastructure, Electronics, Gold Colloid, Materials Testing, Microchemistry, Miniaturization, Molecular Sequence Data, Nucleic Acid Denaturation, Nucleic Acid Hybridization, Particle Size, Sulfhydryl Compounds, Base Sequence, DNA

Read this article at

ScienceOpenPublisherPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Colloidal particles of metals and semiconductors have potentially useful optical, optoelectronic and material properties that derive from their small (nanoscopic) size. These properties might lead to applications including chemical sensors, spectroscopic enhancers, quantum dot and nanostructure fabrication, and microimaging methods. A great deal of control can now be exercised over the chemical composition, size and polydispersity of colloidal particles, and many methods have been developed for assembling them into useful aggregates and materials. Here we describe a method for assembling colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates. The method involves attaching to the surfaces of two batches of 13-nm gold particles non-complementary DNA oligonucleotides capped with thiol groups, which bind to gold. When we add to the solution an oligonucleotide duplex with 'sticky ends' that are complementary to the two grafted sequences, the nanoparticles self-assemble into aggregates. This assembly process can be reversed by thermal denaturation. This strategy should now make it possible to tailor the optical, electronic and structural properties of the colloidal aggregates by using the specificity of DNA interactions to direct the interactions between particles of different size and composition.

      Related collections

      Author and article information

      Journal
      10.1038/382607a0
      8757129

      Comments

      Comment on this article