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      A DNA-based method for rationally assembling nanoparticles into macroscopic materials.

      Nature

      chemistry, Temperature, ultrastructure, Electronics, Gold Colloid, Materials Testing, Microchemistry, Miniaturization, Molecular Sequence Data, Nucleic Acid Denaturation, Nucleic Acid Hybridization, Particle Size, Sulfhydryl Compounds, Base Sequence, DNA

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          Abstract

          Colloidal particles of metals and semiconductors have potentially useful optical, optoelectronic and material properties that derive from their small (nanoscopic) size. These properties might lead to applications including chemical sensors, spectroscopic enhancers, quantum dot and nanostructure fabrication, and microimaging methods. A great deal of control can now be exercised over the chemical composition, size and polydispersity of colloidal particles, and many methods have been developed for assembling them into useful aggregates and materials. Here we describe a method for assembling colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates. The method involves attaching to the surfaces of two batches of 13-nm gold particles non-complementary DNA oligonucleotides capped with thiol groups, which bind to gold. When we add to the solution an oligonucleotide duplex with 'sticky ends' that are complementary to the two grafted sequences, the nanoparticles self-assemble into aggregates. This assembly process can be reversed by thermal denaturation. This strategy should now make it possible to tailor the optical, electronic and structural properties of the colloidal aggregates by using the specificity of DNA interactions to direct the interactions between particles of different size and composition.

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          Journal
          10.1038/382607a0
          8757129

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