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      Oxidative stress shortens telomeres

      Trends in Biochemical Sciences

      Elsevier BV

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          Abstract

          Telomeres in most human cells shorten with each round of DNA replication, because they lack the enzyme telomerase. This is not, however, the only determinant of the rate of loss of telomeric DNA. Oxidative damage is repaired less well in telomeric DNA than elsewhere in the chromosome, and oxidative stress accelerates telomere loss, whereas antioxidants decelerate it. I suggest here that oxidative stress is an important modulator of telomere loss and that telomere-driven replicative senescence is primarily a stress response. This might have evolved to block the growth of cells that have been exposed to a high risk of mutation.

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          Author and article information

          Journal
          Trends in Biochemical Sciences
          Trends in Biochemical Sciences
          Elsevier BV
          09680004
          July 2002
          July 2002
          : 27
          : 7
          : 339-344
          Article
          12114022
          © 2002

          https://www.elsevier.com/tdm/userlicense/1.0/

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