There is ample ground and good motives for interdisciplinary engagement between theology and the 'new' anthropology of Christianity. Theologians can learn much about the character of the church in all its plurality from the often insightful descriptions of anthropologists who have recently started to take a strong interest in Christianity. On the other hand, theologians can help anthropologists come to more complex understandings of the meaning of Christianity. Concerning contrasting anthropological perspectives of anti-essentialism and culture theory regarding the nature of Christianity, this article suggested that the work of missiologists, such as Andrew Walls, might usefully aid the progression of the debate and referred to the historical interplay and conflict between Christianity and indigenous knowledge in southern Africa by way of illustrating this point. The argument pursued in this article hinges on the prioritising of an interdisciplinary approach in theological studies, a cause which Prof. Julian Müller has long championed. Therefore, this contribution sought to honour his legacy by illustrating a further avenue of interdisciplinary engagement.