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      Polymeric nanoparticles for colon cancer therapy: overview and perspectives

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Colorectal cancer (CRC) is the third-most common malignant tumour and is associated with high morbidity and mortality worldwide.

          Abstract

          Colorectal cancer (CRC) is the third-most common malignant tumour and is associated with high morbidity and mortality worldwide. This review summarizes the recent progress in the development of polymeric nanoparticle systems for colon cancer therapy.

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          Most cited references101

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          Biodegradable polymers as biomaterials

          Lakshmi Nair, Cato T. Laurencin (2007)
          Article 0 comments Cited 727 times – based on 0 reviews     Review now
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            CD44: from adhesion molecules to signalling regulators.

            Helmut Ponta, Larry Sherman, Peter A Herrlich (2003)
            Cell-adhesion molecules, once believed to function primarily in tethering cells to extracellular ligands, are now recognized as having broader functions in cellular signalling cascades. The CD44 transmembrane glycoprotein family adds new aspects to these roles by participating in signal-transduction processes--not only by establishing specific transmembrane complexes, but also by organizing signalling cascades through association with the actin cytoskeleton. CD44 and its associated partner proteins monitor changes in the extracellular matrix that influence cell growth, survival and differentiation.
            Article 0 comments Cited 586 times – based on 0 reviews     Review now
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              Nanoparticle-based targeted drug delivery.

              Rajesh Singh, James W. Lillard (2009)
              Nanotechnology could be defined as the technology that has allowed for the control, manipulation, study, and manufacture of structures and devices in the "nanometer" size range. These nano-sized objects, e.g., "nanoparticles", take on novel properties and functions that differ markedly from those seen from items made of identical materials. The small size, customized surface, improved solubility, and multi-functionality of nanoparticles will continue to open many doors and create new biomedical applications. Indeed, the novel properties of nanoparticles offer the ability to interact with complex cellular functions in new ways. This rapidly growing field requires cross-disciplinary research and provides opportunities to design and develop multifunctional devices that can target, diagnose, and treat devastating diseases such as cancer. This article presents an overview of nanotechnology for the biologist and discusses the attributes of our novel XPclad((c)) nanoparticle formulation that has shown efficacy in treating solid tumors, single dose vaccination, and oral delivery of therapeutic proteins.
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                Author and article information

                Journal
                Journal ID (publisher-id): JMCBDV
                Title: Journal of Materials Chemistry B
                Abbreviated Title: J. Mater. Chem. B
                Publisher: Royal Society of Chemistry (RSC)
                ISSN (Print): 2050-750X
                ISSN (Electronic): 2050-7518
                Publication date Created: 2016
                Publication date (Electronic): 2016
                Volume: 4
                Issue: 48
                Pages: 7779-7792
                Affiliations
                [1 ]School of Engineering
                [2 ]Sun Yat-sen University
                [3 ]Guangzhou
                [4 ]P. R. China
                [5 ]Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization
                [6 ]Chengdu Institute of Biology
                [7 ]Chinese Academy of Sciences
                [8 ]Chengdu 610041
                [9 ]China
                [10 ]Materials Science and Engineering Program
                [11 ]University of California San Diego
                [12 ]La Jolla
                [13 ]USA
                [14 ]Key Laboratory for Stem Cells and Tissue Engineering
                [15 ]Ministry of Education
                Article
                DOI: 10.1039/C6TB01925K
                PubMed ID: 32263770
                SO-VID: 4e574689-a4d3-4e1f-844e-6c197613ffa5
                Copyright © © 2016
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