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      Serum 25-Hydroxyvitamin D in Patients with Chronic Renal Failure on Long-Term Treatment with High Doses of Vitamin D 2

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          The present study was aimed at answering the following two questions: (1) What is the effect of high dose vitamin D treatment on the serum level of 25-hydroxyvitamin D (25-OH-D) in patients with chronic renal failure (CRF) ? (2) Is there any effect of urinary protein loss on the serum 25-OH-D levels during treatment with pharmacological doses of vitamin D? 42 patients with CRF were studied. They were treated conservatively by a low protein diet and received 15 mg of vitamin D<sub>2</sub> once a week. Long-term administration of vitamin D caused a significant (5- to 7-fold) increase of plasma 25-OH-D level irrespective of the degree of proteinuria. This increase was noted only during the first 5 months of vitamin D<sub>2</sub> treatment. Surprisingly only in some patients moderate hypercalcemia ( > 2.75 mmol/l) was found. From the results obtained it is concluded that (1) patients with CRF differ from normal subjects in handling of high doses of vitamin D and (2) high dosage treatment with vitamin D may prevent hypocalcemia in patients with CRF in spite of high proteinuria.

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          Author and article information

          S. Karger AG
          02 December 2008
          : 26
          : 3
          : 116-120
          St. Josefs Hospital, Research Clinic of Nutrition Potsdam-Rehbrücke and Department of Nephrology, Institute of Internal Diseases, Silesian School of Medicine, Katowice
          181965 Nephron 1980;26:116–120
          © 1980 S. Karger AG, Basel

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          Pages: 5
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