Plasma levels of Apolipoprotein A1 and Lecithin:Cholesterol Acyltransferase in type 2 diabetes mellitus: Correlations with haptoglobin phenotypes.

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Abstract

Previous studies have demonstrated that hemoglobin-haptoglobin (Hb-Hp) complex plays a role in developing vascular complications in type 2 diabetes mellitus (T2DM). The complexes bind with Apolipoprotein A1 (ApoA1) of high-density lipoprotein (HDL), affecting the function of Lecithin:Cholesterol Acyltransferase (LCAT), and impairing the reverse cholesterol transport mechanism (RCT). This study investigated the influence of Hp phenotypes on serum levels of ApoA1 and LCAT in patients with T2DM.

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Journal

Journal ID (iso-abbrev): Diabetes Metab Syndr

Title: Diabetes & metabolic syndrome

Publisher: Elsevier BV

ISSN (Electronic): 1878-0334

ISSN (Print): 1871-4021

Publication date (Electronic): Dec 2017

Volume: 11 Suppl 2

Affiliations

[1 ] Department of Medical Lab Sciences, College of Health Sciences, University of Sharjah, United Arab Emirates; Metabolic Syndrome and Related Disorders (MSRD) Research Group, Research Institute of Health and Medical Sciences, University of Sharjah, United Arab Emirates. Electronic address: sawadallah@sharjah.ac.ae.

[2 ] Department of Medical Lab Sciences, College of Health Sciences, University of Sharjah, United Arab Emirates; Metabolic Syndrome and Related Disorders (MSRD) Research Group, Research Institute of Health and Medical Sciences, University of Sharjah, United Arab Emirates.

[3 ] Department of Medical Lab Sciences, College of Health Sciences, University of Sharjah, United Arab Emirates.

[4 ] Medical Services of the Ministry of Interior, Sharjah, United Arab Emirates.

Article

Publisher Item ID: S1871-4021(17)30077-2

DOI: 10.1016/j.dsx.2017.04.001

PubMed ID: 28416369

SO-VID: 4e61ff86-59db-45e2-a309-f5a037b2958c

History

Keywords: Type 2 diabetes,Apolipoprotein A1,Haptoglobin,LCAT

Data availability:

Keywords: Type 2 diabetes, Apolipoprotein A1, Haptoglobin, LCAT

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