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      Noninvasive label-free nanoplasmonic optical imaging for real-time monitoring of in vitro amyloid fibrogenesis.

      1 ,
      Nanoscale
      Royal Society of Chemistry (RSC)

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          Abstract

          It is important to develop a noninvasive label-free detection method to monitor dynamic phenomena in biology and medicine. Here, we utilize nanoplasmonic optical imaging as the noninvasive and label-free method in order to monitor in vitro amyloid fibrogenesis in real-time, which is considered as the primary pathological mechanism of Alzheimer's disease. Using Rayleigh scattering of gold nanoplasmonic probes (GNPs), which have an enhanced scattering optical cross-section due to the surface plasmon resonance, we accomplished efficient tracking of the random movements of the GNPs in Aβ solution, and quantified the kinetics of the fibrogenesis. We expect that this noninvasive and label-free in vitro method can be utilized in monitoring in a wide range of other research fields as well. As future applications, we can envision long-term monitoring in neuronal cells to elucidate the mechanism of amyloid growth and NIR-based in vivo imaging with nanoplasmonic optical antennas for gene delivery, photonic gene circuits, and monitoring toward the theranostics of neurodegenerative diseases.

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          Author and article information

          Journal
          Nanoscale
          Nanoscale
          Royal Society of Chemistry (RSC)
          2040-3372
          2040-3364
          Apr 07 2014
          : 6
          : 7
          Affiliations
          [1 ] Department of Biosystems Science and Engineering, ETH Zurich, Basel, CH 4056, Switzerland.
          Article
          10.1039/c3nr06269d
          24598888
          4e84c53c-5973-46bf-ad91-b9a8f914e2bf
          History

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